Accès ouvert

Development of mucoadhesive solid lipid nanoparticles for enhanced oral bioavailability and antimalarial efficacy of artemether/lumefantrine

Article scientifique 2026 Autre

Résumé

Purpose: To report the development of mucoadhesive solid lipid nanoparticles (SLNs) to enhance oral bioavailability and antimalarial efficacy of artemether and lumefantrine. Methods: The SLNs were prepared via hot emulsion–ultrasonication using a lipid matrix composed of dika fat (Irvingia gabonensis) and Phospholipon® 90H. Chitosan coating was applied to confer mucoadhesive properties and prolong gastrointestinal residence time. Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) were employed to determine the drug-excipient interaction and thermal properties of the nanoparticles, respectively. Antimalarial properties of the formulated nanoparticles were carried out in vivo using Plasmodium berghei-infected Wistar albino mice. Results: The SLNs, formulated as individual and co-drug-loaded systems, achieved high encapsulation efficiencies (> 99 % for artemether; > 92 % for lumefantrine). Co-loading improved drug release compared to single-drug SLNs (artemether: 86.2 vs. 58.7 %; lumefantrine: 74.8 vs. 63.8 % over 6 – 8 h). The nanoparticles were spherical, with mean diameters 91.3 – 140.1 nm and polydispersity indices < 0.42. Fourier transform infrared spectroscopy and DSC analyses confirmed drug–excipient compatibility and stable incorporation of both drugs within the lipid matrix. In vivo evaluation in Plasmodium berghei-infected Wistar albino mice revealed a dose-dependent, statistically significant (p < 0.05) reduction in parasitemia for the SLN formulations compared to control. Conclusion: Chitosan-coated SLNs offer a promising platform for oral delivery of artemether-lumefantrine, with potential to overcome current limitations in bioavailability and therapeutic consistency in malaria treatment.

Citer ce document

Ossai, E., Pe, U., Agbom, C., Ossai, E., Mumuni, M., Ezike, C., Mbah, C. (2026). Development of mucoadhesive solid lipid nanoparticles for enhanced oral bioavailability and antimalarial efficacy of artemether/lumefantrine. https://doi.org/10.4314/tjpr.v25i6.2

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

Emmanuel Ossai Ugwuoke Pe Chukwuemeka Agbom Edith Ossai Momoh Mumuni Christian Ezike C J Mbah

Statistiques

Consultations : 1

Téléchargements : 0