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Interplay of Transcription Factor 7-Like-2 Polymorphisms with Type 2 Diabetes Mellitus in a Ghanaian Population

Article scientifique 2021 Anglais

Résumé

Abstract Background Type-2 diabetes mellitus (T2DM) have been strongly associated with single nucleotide polymorphisms (SNPs) in the TCF7L2 gene. This study investigated the interplay between rs12255372 and rs7903146 with T2DM in a Ghanaian population. Methods A case-control design was used for this study. A total of 106 T2DM patients and 110 apparently healthy control participants were selected. Basic data collected included body mass index, blood pressure and socio-demographics. Fasting blood samples were collected and used for serum lipid analysis, HbA1c, glucose estimation and DNA extraction. Common and allele-specific primers were designed for genotyping using the Modified Tetra-Primer Amplification assay. Associations were evaluated using logistic regression models. Results The rs7903146 risk variant was significantly associated with 2.16 vs 4.06 increased odds for T2DM in patients < 60 years vs ≥ 60 years. Both rs7903146 and rs12255372 were significantly associated with increased odds of T2DM in women, overweight/obese; negative T2DM family history and low-HDL-C. In a multivariate model, rs7903146 but not rs12255372 was significantly associated with 2.18, 5.01 and 2.25 increased odds of T2DM, under the codominant, recessive and additive model, respectively (p < 0.05). Haplotype analysis showed that rs7903146 and rs12255372 SNPs are weakly associated (D’=0.021; r2 = 0.0001). Conclusion The association between rs7903146 and rs12255372 with T2DM looks to be more highly associated in a subgroup- women and those without T2DM family history, yet have cardiometabolic risk.

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Obirikorang, C., Adu, E., Acheampong, E., Anto, E., Quaye, L., Amoah, B., Annani-Akollor, M., Kwakye, A., Fokuoh, F., Appiah, M., Nyarko, E., Aidoo, F., Adua, E., Afrifa‐Yamoah, E., Balmer, L., Wang, W. (2021). Interplay of Transcription Factor 7-Like-2 Polymorphisms with Type 2 Diabetes Mellitus in a Ghanaian Population. https://doi.org/10.21203/rs.3.rs-244726/v1

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Auteur(s)

Christian Obirikorang Evans Asamoah Adu Emmanuel Acheampong Enoch Odame Anto Lawrence Quaye Brodrick Yeboah Amoah Max Efui Annani-Akollor Aaron Siaw Kwakye Foster Fokuoh Michael Appiah E Nyarko Freeman Aidoo Eric Adua Ebenezer Afrifa‐Yamoah Lois Balmer Wei Wang

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