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T-cell responses to SARS-CoV-2 in unexposed South African women

Article scientifique 2021 Anglais

Résumé

Background : A potential explanation for the fact that the high rate of infection of SARS-CoV-2 in South Africa did not translate into high rates of severe illness and death may be the presence of cross-reactive immunity induced by common cold coronaviruses (CCoV). Methods : We used SARS-CoV-2 peptide pools and whole virus antigen to stimulate peripheral blood mononuclear cells collected pre-2020 from South African women. Dual-colour FluoroSpot assay was used to measure interferon gamma (IFNγ) and interleukin 2 (IL2) production. Results : Among the 97 study participants, IFNγ responses were observed in 29.9% of the women and IL2 among 39.2%. Overall, 51.6% of women demonstrated response to at least one stimulant. Conclusion : We demonstrate the presence of cross-reactive immunity to SARS-CoV-2, which might have been induced by past exposure to CCoV.

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Nunes, M., Johnson, M., Kwatra, G., Weinberg, A., Madhi, S. (2021). T-cell responses to SARS-CoV-2 in unexposed South African women. https://doi.org/10.12688/gatesopenres.13373.1

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Auteur(s)

Marta C. Nunes Michael Johnson Gaurav Kwatra Adriana Weinberg Shabir A. Madhi

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