GWAS identifies genetic clusters of cardiometabolic risk factors in continental Africans

Résumé

Abstract Cardiometabolic risk factors (CMRFs) are a growing global health concern. Here, we set out to identify novel genetic loci associated with CMRFs in two continental African populations, Ugandans and South African Zulu’s. Thus, we conducted a multivariate meta-analysis with META-SCOPA; where six CMRFs comprising of waist circumference (WC), triglycerides (TG), high-density lipoprotein (HDL), systolic blood pressure (SBP), diastolic blood pressure (DBP), and glycated hemoglobin A1c (HbA1c) were used. META-SCOPA identified five novel loci and its Multi-marker Analysis of GenoMic Annotation (MAGMA) gene-set analysis showed an association with human histone acetyltransferase/male sex-lethal (MSL) complex. Fine-mapping, colocalization, tissue expression analyses, and phenome-wide association study (PheWAS) were also implemented to better understand the meta-analysis findings. Furthermore, as a supplement a principal component analysis (PCA) GWAS was also performed on the same six CMRFs. The first principal component denoted cardiometabolic_PC1 was driven mostly by DBP and SBP. Five novel, significant loci were identified after the meta-analysis. Ultimately, our novel loci and gene-sets offer fresh insights into the clustering of CMRFs and propose a unique link to the human histone acetyltransferase/MSL complex, as well as circulatory system processes in continental Africans. Additional large-scale efforts in Africa are needed to understand the clustering of CMRFs.

Citer ce document

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0