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Crystal structure and anticancer screening of 2-(4-acetylphenylcarbamoyl)phenyl acetate

Article scientifique 2022 Anglais

Résumé

Abstract Aspirin-based 2-(4-acetylphenylcarbamoyl)phenyl acetate (3) has been synthesized through the reaction of 2-(chlorocarbonyl)phenyl acetate and 1-(4-aminophenyl)ethanone in the presence of triethyl amine. Assessment of anti-proliferative properties of the compound on NCI 60-cell line panel revealed remarkable to moderate anti-cancer activity. Single-crystal x-ray diffraction and spectroscopic techniques were used to validate the chemical structure of the compound.

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Mohamed‐Ezzat, R., Kariuki, B., Srour, A. (2022). Crystal structure and anticancer screening of 2-(4-acetylphenylcarbamoyl)phenyl acetate. https://doi.org/10.21203/rs.3.rs-1933504/v1

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Reham A. Mohamed‐Ezzat Benson M. Kariuki Aladdin M. Srour

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