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A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

Article scientifique 2016 Anglais

Résumé

The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.

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Mathias, R., Taub, M., Gignoux, C., Fu, W., Musharoff, S., O’Connor, T., Vergara, C., Torgerson, D., Pino‐Yanes, M., Shringarpure, S., Huang, L., Rafaels, N., Boorgula, M., Johnston, H., Ortega, V., Levin, A., Song, W., Torres, R., Padhukasahasram, B., Eng, C., Mejia-Mejia, D., Ferguson, T., Qin, Z., Scott, A., Yazdanbakhsh, M., Wilson, J., Marrugo, J., Lange, L., Kumar, R., Avila, P., Williams, L., Watson, H., Ware, L., Olopade, C., Olopade, O., Oliveira, R., Ober, C., Nicolae, D., Meyers, D., Mayorga, A., Knight‐Madden, J., Hartert, T., Hansel, N., Foreman, M., Ford, J., Faruque, M., Dunston, G., Caraballo, L., Burchard, E., Bleecker, E., Araújo, M., Herrera-Paz, E., Gietzen, K., Grus, W., Bamshad, M., Bustamante, C., Kenny, E., Hernandez, R., Beaty, T., Ruczinski, I., Akey, J., Campbell, M., Chavan, S., Foster, C., Gao, L., Horowitz, E., Ortiz, R., Potee, J., Gao, J., Hu, Y., Deshpande, A., Locke, D., Grammer, L., Kim, K., Schleimer, R., Vega, F., Szpiech, Z., Oluwole, O., Arinola, G., Correa, A., Musani, S., Chong, J., Nickerson, D., Reiner, A., Maul, P., Maul, T., Martínez, B., Meza, C., Ayestas, G., Landaverde-Torres, P., Erazo, S., Martinez, R., Mayorga, L., Ramos, H., Saenz, A., Varela, G., Vasquez, O., Samms‐Vaughan, M. (2016). A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. https://doi.org/10.1038/ncomms12522

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Auteur(s)

Rasika A. Mathias Margaret A. Taub Christopher R. Gignoux Wenqing Fu Shaila Musharoff Timothy D. O’Connor Candelaria Vergara Dara G. Torgerson Maria Pino‐Yanes Suyash Shringarpure Lili Huang Nicholas Rafaels Meher Preethi Boorgula H. Richard Johnston Victor E. Ortega Albert M. Levin Wei Song Raúl Torres Badri Padhukasahasram Celeste Eng Delmy-Aracely Mejia-Mejia Trevor S. Ferguson Zhaohui Qin Alan F. Scott Maria Yazdanbakhsh James G. Wilson Javier Marrugo Leslie A. Lange Rajesh Kumar Pedro C. Avila L. Keoki Williams Harold Watson Lorraine B. Ware Christopher O. Olopade Olufunmilayo I. Olopade Ricardo Riccio Oliveira Carole Ober Dan L. Nicolae Deborah A. Meyers Alvaro Mayorga Jennifer Knight‐Madden Tina V. Hartert Nadia N. Hansel Marilyn G. Foreman Jean G. Ford Mezbah U. Faruque Georgia M. Dunston Luis Caraballo Esteban G. Burchard Eugene R. Bleecker Maria Ilma Araújo Edwin Francisco Herrera-Paz Kimberly Gietzen Wendy E. Grus Michael J. Bamshad Carlos D. Bustamante Eimear E. Kenny Ryan D. Hernandez Terri H. Beaty Ingo Ruczinski Joshua M. Akey Monica Campbell Sameer Chavan Cassandra Foster Li Gao Edward A. Horowitz Romina Ortiz Joseph Potee Jingjing Gao Yi‐Juan Hu Aniket Deshpande Devin P. Locke Leslie C. Grammer Kwang-YounA Kim Robert P. Schleimer Francisco M. De La Vega Zachary A. Szpiech Oluwafemi Oluwole Ganiyu Arinola Adolfo Correa Solomon K. Musani Jessica X. Chong Deborah A. Nickerson Alex P. Reiner Pissamai Maul Trevor Maul B. Martínez Catherine Meza Gerardo Ayestas Pamela Landaverde-Torres Said Omar Leiva Erazo Rosella Martinez L Mayorga Hector Ramos Allan Saenz Gloria Varela Olga Marina Vasquez Maureen Samms‐Vaughan

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