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β-Glucan exacerbates allergic airway responses to house dust mite allergen

Article scientifique 2016 Anglais

Résumé

β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

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Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G., Williams, D., Lambrecht, B., Brombacher, F., Brown, G. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. https://doi.org/10.1186/s12931-016-0352-5

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Auteur(s)

Sabelo Hadebe Frank Kirstein Kaat Fierens Pierre Redelinghuys Graeme I. Murray David L. Williams Bart N. Lambrecht Frank Brombacher Gordon D. Brown

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