Review of: "Toxicological evaluation of aqueous extracts of Clematis hirsuta and Rhamnus prinoides"
Résumé
Article revisionDeveloping countries rely on traditional herbal medicine to meet their primary healthcare needs.This traditional herbal medicine has quickly grown to the point of becoming popular due to its ease of use, low cost, proven effectiveness, and decreased perceived side effects.Nevertheless, the safety of herbal medicine still needs to be proven.Popular belief states that all traditional medicines are harmless to the health of consumers.This is not always true because the difference between medicine and poison is the dose.The authors, therefore, conducted this study to verify the toxicological effects of Clematis hirsuta leave and Rhamnus prinoides roots on Wistar rats.The authors conducted two experimental studies.Acute oral toxicity according to OECD guideline 423.In this study, the authors determined the LD50 and the effects of treatment with different extracts on the body weight variation, water and food intake and some behavioral parameters of 21 rats.Repeated oral toxicity for 28 days still following the OECD guideline.The authors used female rats to verify the toxic effects of the different extracts at doses of 25, 75 and 225 mg/kg on the evolution of weight and on some hematological and biochemical parameters.The authors report that the present study investigated the safety of aqueous extracts of Clematis hirsuta leaves and Rhamnus prinoides roots in rats.Toxicological data on aqueous extracts of C. hirsuta leaves were mixed.For example, in the acute toxicity study, rats given 2000 mg/kg aqueous extract of C. hirsuta leaves gained weight relative to rats in the control group without physical signs of toxicity after 24 hours or 14 days.Ironically, rats treated with C. hirsuta had lower food and water consumption rates than rats in the control group.In subacute toxicity, there were no significant changes in weight gain, hematological or biochemical parameters between Clematis hirsuta-treated rats and controls.Administration of aqueous root extract of R. prinoides to Wistar rats did not cause any physical signs of toxicity during the first 24 hours or after 14 days and was associated with significant weight gain compared to the control.However, food and water consumption in rats treated with R. prinoides was lower than that of rats in the control group.Moreover, there were no significant differences in weight gain, hematological or biochemical parameters between rats and controls treated with the aqueous extract of the roots of R. prinoides.This study did not evaluate the effects of aqueous extracts of C. hirsuta leaves and R. prinoides roots on major organs in
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