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Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in two Kenyan referral hospitals

Article scientifique 2021 Anglais

Résumé

Abstract The high proportion of SARS-CoV-2 infections that remain undetected presents a challenge to tracking the progress of the pandemic and implementing control measures in Kenya. We determined the prevalence of IgG to SARS-CoV-2 in residual blood samples from mothers attending antenatal care services at 2 referral hospitals in Kenya. We used a validated IgG ELISA for SARS-Cov-2 spike protein and adjusted the results for assay sensitivity and specificity. In Kenyatta National Hospital, Nairobi, seroprevalence in August 2020 was 49.9% (95% CI 42.7-58.0). In Kilifi County Hospital seroprevalence increased from 1.3% (95% CI 0.04-4.7) in September to 11.0% (95% CI 6.2-16.7) in November 2020. There has been substantial, unobserved transmission of SARS-CoV-2 in parts of Nairobi and Kilifi Counties.

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Lucinde, R., Mugo, D., Bottomley, C., Aziza, R., Gitonga, J., Karanja, H., Nyagwange, J., Tuju, J., Wanjiku, P., Nzomo, E., Kamuri, E., Agunda, S., Nyutu, G., Etyang, A., Adetifa, I., Kagucia, E., Uyoga, S., Otiende, M., Otieno, E., Ndwiga, L., Agoti, C., Aman, R., Mwangangi, M., Amoth, P., Kasera, K., Nyaguara, A., Ng’ang’a, W., Ochola, L., Barasa, E., Bejon, P., Tsofa, B., Ochola‐Oyier, L., Warimwe, G., Agweyu, A., Scott, J., Gallagher, K. (2021). Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in two Kenyan referral hospitals. https://doi.org/10.1101/2021.02.05.21250735

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Auteur(s)

Ruth Lucinde Daisy Mugo Christian Bottomley Rabia Aziza John N. Gitonga Henry Karanja James Nyagwange James Tuju Perpetual Wanjiku Eddy Nzomo Evanson Kamuri S. Agunda Gideon Nyutu Anthony Etyang Ifedayo Adetifa E. Wangeci Kagucia Sophie Uyoga Mark Otiende Edward Otieno Leonard Ndwiga Charles N. Agoti Rashid Aman Mercy Mwangangi Patrick Amoth Kadondi Kasera Amek Nyaguara Wangari Ng’ang’a Lucy Ochola Edwine Barasa Philip Bejon Benjamin Tsofa Lynette Isabella Ochola‐Oyier George M. Warimwe Ambrose Agweyu J. Anthony G. Scott Katherine E. Gallagher

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