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Detection of canine distemper virus (CDV) neutralising antibodies in small ruminants during peste-des-petits-ruminants virus (PPRV) surveillance in Zambia

Article scientifique 2025 Anglais

Résumé

Canine distemper virus (CDV) is endemic in Zambia, while peste-des-petits-ruminants virus (PPRV) has not been detected. This study screened 962 farmed goats and 237 small ruminants at informal markets for PPRV antibodies using c-ELISA. A subset (n = 29) was re-analysed with virus neutralisation assays (VNA) for antibodies to PPRV and CDV due to cross-reactivity concerns. c-ELISA indicated 6.44% PPRV seroprevalence on farms and 3.80% at markets. While VNA detected no PPRV antibodies, 45% (13/29) tested positive for CDV, possibly suggesting cross-reactivity. Given the study's limitations, further research is needed to determine whether PPRV is present in Zambia and assess potential cross-reactivity.

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Lysholm, S., Logan, N., Lindahl, J., Berg, M., Johansson, E., Bergkvist, P., Dautu, G., Chazya, R., Willett, B., Munyeme, M., Wensman, J. (2025). Detection of canine distemper virus (CDV) neutralising antibodies in small ruminants during peste-des-petits-ruminants virus (PPRV) surveillance in Zambia. https://doi.org/10.1186/s12917-025-04732-w

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Auteur(s)

Sara Lysholm Nicola A. Logan Johanna F. Lindahl Mikael Berg Elin Johansson Pernilla Karlsson Bergkvist George Dautu Ricky Chazya Brian J. Willett Musso Munyeme Jonas Johansson Wensman

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