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Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis

Article scientifique 2019 Anglais

Résumé

South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.

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Bouton, T., Vos, M., Ragan, E., White, L., Zyl, L., Theron, D., Horsburgh, C., Warren, R., Jacobson, K. (2019). Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis. https://doi.org/10.1371/journal.pone.0223308

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Auteur(s)

Tara C. Bouton Margaretha de Vos Elizabeth J. Ragan Laura F. White Leonie Van Zyl Danie Theron C. Robert Horsburgh Robin M. Warren Karen R. Jacobson

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