Association of balance impairment with risk of incident cardiovascular diseases among older adults

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Abstract Background: Rapid decline in balance is a hallmark of aging, elevating the risk of falls and other age-related geriatric illnesses among older adults. Objective: Our aim was to assess whether impairment in balance function is associated with the risk of incident CVD in older adults. Design: Retrospective cohort analysis Participants: A total of 129,024 participants who had undergone health screening between 2002 and 2009 were derived the National Health Insurance Service-Senior. Main Measures: Balance impairment was evaluated using the open-eyes one-leg standing (OLS) test. The association between balance impairment and incident CVD was analyzed using the Cox proportional hazards regression model. All participants were followed up with until either the date of the first incident of CVD, death, or 31 December 2019. Key Results: Those with abnormal balance function (<10 seconds in OLS test) had a higher risk of CVD (adjusted hazard ratio [aHR] 1.23, CI 1.16-1.31). The association was significant in both the obese and the non-obese, but it seemed to be more pronounced in the latter. Results were supported by sensitivity analyses that did not include cases of CVD development in the first 1, 2, or 3 years and that used a different criterion to define balance dysfunction (<9 seconds in OLS test). Conclusions: Older adults with balance impairment were found to have an increased risk of incident CVD. Patients with impaired balance function may be a high-risk population who require preventive managements against CVD.

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