Synthesis of new 2-pyridinone and 2-iminochromene derivatives bearing biologically active pyrrole moiety as expected antibacterial and antifungal agents

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Abstract As attempt to cope the microbial drug-resistance, new derivatives of 2-pyridinone and 2-iminochromene with biologically active pyrrole core were designed and synthesized. The 2-pyridone derivatives were synthesized via ring closure of 2-cyano-N'-((1-methyl-1H-pyrrol-2-yl)methylene)acetohydrazide by 1,3-dicarbonyl compound (acetylacetone) or arylidene malononitriles. The 2-iminochromene derivatives were obtained via the cyclocondensation reaction of cyanoacetamide by o-hydroxy aldehyde derivatives to furnish chromene derivatives. The antibacterial and antifungal activities for the synthesized compounds were investigated. All of the 2-pyridinone and 2-iminochromene derivatives showed moderate activity toward both of G -ve and G + ve bacteria (S. aureus).

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