Can the current Mpox affect the heart? A Systematic Review of case series and case report

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Abstract Background Till now all symptoms of the Mpox virus aren’t known, and we still discover new symptoms associated with Mpox. Accordingly, we aimed to summarize evidence about cardiac complications associated with the Mpox virus. Methods On 1st Dec. 2022, a systematic search of the literature was done to locate papers that discuss any cardiac complications associated with Mpox, then data were analyzed qualitatively. Results Seven articles including eleven cases that reported cardiovascular complications of the disease were included in the review, it was reported that six cases previously had sex with men that reveals the importance of the sexual route in the disease transmission. All cases have different forms of cardiac complications such as acute myocarditis, pericarditis, pericardial effusion, and myopericarditis. Conclusion The first study summarizes cardiac complications of Mpox infection. It indicates the possibility of cardiac complications of Mpox infection. The clinical suspicion is based primarily upon the temporal relationship. Further research is needed to identify the pathological mechanism underlying Mpox-associated heart injury.Cases with pericarditis are treated with Colchicine 1–2 mg as an initial dose that will be decreased gradually. Cases with myocarditis are treated by supportive care, or cardioprotective treatment with bisoprolol and ramipril. Tecovirimat is used as an antiviral drug for a 14-day duration.

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