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Population genomics of Plasmodium ovale species in sub-Saharan Africa

Article scientifique 2024 Anglais

Résumé

Abstract Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we present a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates are predominantly monoclonal (43/45), with their genetic similarity aligning with geography. Pow shows lower average nucleotide diversity (1.8×10−4) across the genome compared to Poc (3.0×10−4) (p < 0.0001). Signatures of selective sweeps involving the dihydrofolate reductase gene have been found in both species, as are signs of balancing selection at the merozoite surface protein 1 gene. Differences in the nucleotide diversity of Poc and Pow may reflect unique demographic history, even as similar selective forces facilitate their resilience to malaria control interventions.

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Carey-Ewend, K., Popkin-Hall, Z., Simkin, A., Muller, M., Hennelly, C., He, W., Moser, K., Gaither, C., Niaré, K., Aghakanian, F., Feleke, S., Brhane, B., Phanzu, F., Kashamuka, M., Aydemir, Ö., Sutherland, C., Ishengoma, D., Ali, I., Ngasala, B., Kalonji, A., Tshefu, A., Parr, J., Bailey, J., Juliano, J., Lin, J. (2024). Population genomics of Plasmodium ovale species in sub-Saharan Africa. https://doi.org/10.1038/s41467-024-54667-3

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Auteur(s)

Kelly Carey-Ewend Zachary R. Popkin-Hall Alfred Simkin Meredith Muller Christopher M. Hennelly Wenqiao He Kara A. Moser Claudia Gaither Karamoko Niaré Farhang Aghakanian Sindew Mekasha Feleke Bokretsion G. Brhane Fernandine Phanzu Melchior Mwandagalirwa Kashamuka Özkan Aydemir Colin J. Sutherland Deus S. Ishengoma Innocent Mbulli Ali Billy Ngasala Albert Kalonji Antoinette Tshefu Jonathan B. Parr Jeffrey A. Bailey Jonathan J. Juliano Jessica T. Lin

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