Sub-Acute Effects of Hot Aqueous Arachis hypogaea Pericarp Extract on Serum Antioxidant Markers Following Doxorubicin Administration in Male Wistar Rats

Résumé

The toxicity of Doxorubicin, an anthracyclic antibiotic, a valuable drug as the drug of choice for treatment of various cancer types, has been an issue of great concern. The drug generates reactive oxygen species (ROS), which induce oxidative stress and inflammation in body tissues; hence, there is a need for adjuvant therapy while monitoring the concentration of Doxorubicin in serum. This study aims to evaluate the antioxidant properties of Arachis hypogaea L. (Fabaceae family) pericarp, commonly known as groundnut peel, and its subacute effect on serum antioxidant markers following doxorubicin administration. Researchers have studied several antioxidant markers, including superoxide dismutase, lipid peroxidation, glutathione peroxidase, and catalase. These markers indicate the balance between the body's antioxidant defence and oxidative damage. Results showed a significant decline in oxidative stress and a reduction in the prospects of tissue injury induced by Doxorubicin administration. Hence, Arachis hypogaea pericarp extract can play a protective role against Doxorubicin-induced oxidative stress and toxicity in serum, thereby enhancing antioxidant defence.

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