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Benign breast disease and breast cancer risk in African women: A case-control study

Article scientifique 2023 Anglais

Résumé

Purpose: To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women. Methods: BC cases and matched controls were enrolled in three sub-Saharan African countries, Nigeria Cameroon, and Uganda, between 1998-2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD. Results: Of 6418 participants, 55.7% (3572) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] = 1.47, 95% CI: 1.13-1.91). Biopsy-confirmed BBD was associated with BC (aOR = 3.11, 95% CI: 1.78-5.44). BBD did not significantly mediate the effects of any of the selected BC risk factors. Conclusions: In this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.

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Omoleye, O., Freeman, J., Oluwasanu, M., Adeniji-Sofoluwe, A., Woodard, A., Aribisala, B., Adejumo, P., Ntekim, A., Makumbi, T., Ndom, P., Ajayi, I., Olopade, O., Huo, D. (2023). Benign breast disease and breast cancer risk in African women: A case-control study. https://doi.org/10.21203/rs.3.rs-3301977/v1

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Auteur(s)

Olasubomi Jimmy Omoleye Jincong Q. Freeman Mojisola Oluwasanu Adenike Adeniji-Sofoluwe Anna Woodard Benjamin S. Aribisala Prisca Olabisi Adejumo Atara Ntekim Timothy Makumbi Paul Ndom IkeOluwapo O. Ajayi Olufunmilayo I. Olopade Dezheng Huo

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