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Matrix metalloproteinase-8 level in the peri-implant sulcular fluid around dental implant abutments with different geometries and manufacturing strategies: A randomized controlled trial

Article scientifique 2022 Anglais

Résumé

Abstract Background. The purpose of this clinical trial was to assess soft tissue reaction around custom dental implant abutments by evaluation of Matrix Metalloproteinase-8 (MMP-8) level in peri-implant sulcular fluid (PISF) and clinical parameters. Methods. Thirty participants with missing mandibular first molar were enrolled in this randomized controlled trial. Each participant underwent implant placement following the standard 2-stage surgical protocol. All participants were randomly allocated to one of the two groups; Control Group (n=15): Pre-machined stock titanium abutment, and Study Group (n=15): Custom titanium CAD-CAM abutment. Combined screw- and cement-retained zirconia crowns were used to restore implants. The PISF samples were collected at 1, 3, 6 and 12 months after placement of restorations. MMP-8 level was assessed by Enzyme-Linked ImmunoSorbent Assay. Peri-implant probing depth (PPD), simplified mucosal index (SMI) and modified plaque index (mPI) scores were assessed at all time-points. Crestal bone loss (CBL) was assessed by using bitewing radiographs made at baseline and 12-month time points. Two-way repeated-measures ANOVA and Friedman test were used to analyze data. Results. There was a significant effect of the interaction of time and abutment type where the change in MMP-8 and PPD in CA was higher than in SA. SMI, mPI and CBL recorded no statistical differences between the two groups after one year (P > 0.05). Conclusions. The change in the level of MMP-8 and in PPD after one year is significantly higher in custom abutments. However, this change was of low clinical impact. Trial Registery: the trial was registered in the Pan African Clinical Trial Registry under identification number PACTR201809736563842 (25/ 09/ 2018)

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Raheem, I., Hammad, I., Kader, S., Hadidi, A., Fahmy, R. (2022). Matrix metalloproteinase-8 level in the peri-implant sulcular fluid around dental implant abutments with different geometries and manufacturing strategies: A randomized controlled trial. https://doi.org/10.21203/rs.3.rs-2192748/v1

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Islam M. Abdel Raheem Ihab Hammad Sanaa H. Abdel Kader Abeer S. El Hadidi Rania Fahmy

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