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A novel t (5; 17) (q35; q21) associated with t (8; 21) (q22; q22) in a patient with acute myeloid leukemia: Case report and review of literature

Article scientifique 2023 Anglais

Résumé

Abstract The t (8; 21) (q22; q22) with the resulting RUNX1- RUNX1T1 rearrangement is one of the most common cytogenetic abnormalities in acute myeloid leukemia (AML). It is associated with favorable prognosis. The t (5; 17) (q35; q21) is an uncommon translocation, fuses the gene for the nucleophosmin (NPM) to the retinoic acid receptor α(RARA) and was described essentially in acute promyelocytic leukemia (APL) variant. We present the case of a 19-year-old male patient who developed an AML with t (8 ;21) (q22 ;q22) associated to t(5 ;17)(q35 ;21). Morphology and immunophenotype of the leukemic cells were compatible with AML. The patient received chemotherapy based on cytarabine and anthracycline without all-trans retinoic acid (ATRA) followed by allogenic stem cells transplantation in first remission. To the best of our knowledge, this is the first report of an association between a rare translocation t (5; 17) and t (8;21) in AML. In this report, we will discuss the prognosis of this association as well as the treatment.

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Zahra, K., Cherif, W., Ahmed, G., Regaïeg, H., Nesrine, B., Zaier, M., Mootamri, W., Youssef, Y., Brahem, N., Sennana, H., Khélif, A. (2023). A novel t (5; 17) (q35; q21) associated with t (8; 21) (q22; q22) in a patient with acute myeloid leukemia: Case report and review of literature. https://doi.org/10.21203/rs.3.rs-2748783/v1

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Kmira Zahra Wided Cherif G. Ahmed H. Regaïeg Ben Sayed Nesrine Monia Zaier Wided Mootamri Yosra Ben Youssef Nejia Brahem Halima Sennana Abderrahim Khélif

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