Role of Lyn Immunohistochemical Staining in Progression of Colorectal Carcinoma

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OBJECTIVE: To investigate the immunohistochemical expression of Lyn in colorectal adenocarcinoma with its corresponding lymph node metastasis and correlation with clinicopathological characteristics. METHODS: Immunohistochemical analysis of Lyn expression was performed on 70 colorectal cancer (CRC) tissue specimens of hemicolectomy and their corresponding lymph node metastases. Clinicopathological data, including age, gender, tumor size, location, TNM stage, modified Dukes stage, tumor grade, tumor-infiltrating lymphocytes (TILs), poorly differentiated clusters (PDCs), vascular invasion, and perineural invasion (PNI), were collected and analyzed to assess correlations with Lyn expression. RESULTS: High Lyn expression was observed in 34.3% of CRC cases. Significant associations were found between high Lyn expression and positive nodal metastasis (p < 0.001), higher TNM stage (p = 0.003), and advanced modified Dukes stage (p = 0.001). No significant associations were found between Lyn expression and age, gender, tumor size, primary tumor location, tumor grade, TILs, PDCs, vascular invasion, or PNI (p > 0.05 for all). A significant correlation was observed between Lyn expression in primary tumors and their corresponding lymph node metastases (p = 0.033). CONCLUSION: Lyn expression is significantly associated with unfavorable clinicopathological parameters, which are lymph node metastasis and advanced tumor stage, suggesting its potential role as a prognostic marker in colorectal cancer.

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