Editorial: Microbiota-hormones-gut axis as a therapeutic target for metabolic disorders
Résumé
Editorial on the Research Topic Microbiota-hormones-gut axis as a therapeutic target for metabolic disordersInteractions between the intestinal microbiota, hormones, and the gut itself create a cascade of responses of many types that play an important role in the regulation of metabolic processes.As a result, potential disruptions in this axis will be connected to the development of several metabolic disorders such as obesity, type 2 diabetes and cardiovascular diseases.Additionally, new efforts to treating these conditions have included directly addressing the microbiota-hormone-gut axis via dietary changes, probiotics, prebiotics, antibiotics, and fecal microbiota transplantation.Dietary changes can have an impact on the composition of the gut microbiota as well as the production of hormones involved in metabolic regulation.In the same context, Xu et al., revealed the therapeutic effects of a Chinese herbal formula mixed with metformin on the intestinal microbiota of persons with type 2 diabetes.This study found that the therapy combination improved glycemic control while also having a positive effect on the gut microbiota by increasing the abundance of beneficial bacteria such as Bifidobacterium and Lactobacillus while decreasing the abundance of harmful bacteria such as Clostridium and Streptococcus.These findings are consistent with the report from Liu et al., in relation to antidiabetic drugs based on probiotics or prebiotics that alter microbial diversity and composition, as well as levels of bacterial components and derived metabolites, such as lipopolysaccharide (LPS), short chain fatty acids (SCFA), bile acids, and indoles.The latter are known for their importance in the regulation of the intestinal barrier, the inflammatory response, insulin resistance and glucose homeostasis, via the intestinal microbiota influencing the secretion of intestinal hormones such as GLP-1 and PYY.It has also been demonstrated that persons with type 2 diabetes have a distinct makeup of the gut microbiota when compared to healthy individuals, with a diversity and abundance of helpful bacteria reduced and an excess of potentially harmful bacteria increased (1).Dyslipidemia, another side effect of a metabolic illness, refers to an abnormal level of lipids in the blood, such as cholesterol and triglycerides.It is a prevalent risk factor for major illnesses Frontiers in Endocrinology frontiersin.
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