Editorial: Pharmacometrics—tools to assure optimal medicine use in low- and middle-income countries

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pharmacometrics, low-and lower-middle-income countries, pharmacokinetic/ pharmacodynamic (PK/PD), optimized dosage, communicable and noncommunicable diseases Editorial on the Research Topic Pharmacometrics-tools to assure optimal medicine use in low-and middle-income countries Pharmacometrics is the science of using advanced mathematical and statistical methods based on biology, pharmacology, physiology, and knowledge of the pathophysiology of disease to quantify the relationships between the dose of an administered drug, its time course in the body, and its clinical efficacy and safety in individual patients and whole populations.This methodology optimizes therapy and has become an integral part of modern drug discovery and development and model-informed precision dosing at the patient's bedside.This Research Topic of Frontiers in Pharmacology aimed to address the application of pharmacometrics methodologies in medicines development, individual patient management, and medicines regulation in low-and middle-income countries (LMICs) and promote the discipline of pharmacometrics in LMICs, particularly in Africa.Speakers at the 2022 World Conference on Pharmacometrics (WCoP 2022), held in Cape Town, South Africa, were encouraged to submit manuscripts.The central theme of the three accepted and published manuscripts is infectious diseases, two of which focused on tuberculosis (TB).The fourth published manuscript focused on the placebo effect in pain studies.

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