Is Sortilin an indicator of subclinical atherosclerosis in patients with psoriasis?

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Abstract Introduction: Systemic comorbidities are quite common in psoriasis, which is a chronic inflammatory disease. These comorbidities are important causes of mortality and morbidity. Atherosclerosis and related cardiovascular events are important causes of death at an early age. Atherosclerosis is a condition that can be detected by radiological examination. We aimed to evaluate the role of serum sortilin as possible markers for subclinical atherosclerosis in patients with psoriasis. Methods: Serum levels of sotilin was measured by ELISA in 33 psoriasis patients and in 33 healthy controls. Waist circumference and body mass index of both groups were recorded; Fasting plasma glucose(FPG), HOMA-IR, serum lipid and sortilin levels were measured. Carotid and femoral intima-media thicknesses (CIMT, FIMT) were measured by USG. Demographic characteristics, the severity of psoriasis (PASI), age of onset, total duration and presence of nail involvement of patients included in the study were recorded. Results: The mean serum sortilin level was 6.20 ± 3.11 ng / mL in the patient group and 7.82 ± 4.97 ng / mL in the control group. There was no statistically significant difference between serum sortilin levels in both groups (p = 0.729). There was no statistically significant relationship between serum levels of sortilin and disease severity (p = 0.597). The right and left CIMT values of the patients were significantly higher than the controls (p = 0.012, p = 0.020). There was no significant difference between the two groups in terms of FIMT values. There was a statistically significant relationship between serum sortilin levels and right CIMT in patients (p = 0.031). Discussion: The positive correlation between the level of sortilin and the right CIMT in our patient group confirmed that sortilin may be an indicator of subclinical atherosclerosis in psoriasis patients.

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