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Chronic Paraquat Exposure on Kidney and Vitamin E and C Treatment Benefits

Article scientifique 2023 Anglais

Résumé

Abstract The aim of this study was to evaluate the role of vitamin E and C in managing paraquat-inflicted kidney injury in rat. Exactly 120 rats were grouped A-D with 3 sub-groups (0, VE and VEC) of 10 rats each. All “0” subgroups were orally poisoned with paraquat increasing level of 0.0g/Kg, 0.02g/Kg, 0.04g/Kg and 0.06g/Kg for A, B, C and D respectively every two weeks for 3 months. All subgroup VE were orally treated with 500mg of vitamin E weekly for 3 months and all “VEC” subgroups were treated with 500mg of vitamin E and 2000mg/L of vitamin C weekly for 3 months. Blood samples and kidneys were collected at second and third months, the samples were assessed for kidney function. The results showed that singular vitamin E treatment and in combination with C restored renal function in paraquat-mediated nephrotoxicity in rats.

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Okolonkwo, B., Nyenke, C., Ajibo, D., Ibitoroko, G., Odiabara, K. (2023). Chronic Paraquat Exposure on Kidney and Vitamin E and C Treatment Benefits. https://doi.org/10.58613/jbb332

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Auteur(s)

Benjamin Nnamdi Okolonkwo Clement Ugochukwu Nyenke Doris Nnenna Ajibo George-Opuda Maureen Ibitoroko Kingsley Kalawari Odiabara

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