Resistin Levels In Healthy Non-Diabetes Nigerian-Africans: Effect Of Obesity The ABU Adiporesistin Survey

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Abstract Background Conflicting findings exist on the mechanisms of resistin in obesity and insulin resistance among white populations, as data on these in black Africans are scarce, on account of genetic/geographical differences. Hence, the study aimed to determine plasma resistin levels in Nigerian-Africans and explore its relationship with obesity and selected cardiometabolic risks. Materials and Methods A cross-sectional study on 87 randomly-selected non-diabetes Nigerians of both genders allocated into three study groups: 24 normal weight; 23 overweight and 40 obese groups by the WHO criteria. Fasting Insulin (FI), Homeostasis Model Assessment-Insulin resistance (HOMA-IR) and obesity indices were determined. Plasma resistin was measured via enzyme linked immunosorbent assay. One-way Kruskal-Wallis test determined cardiometabolic parameters across the groups with Spearman’s correlation assessing relationships. Results Resistin levels were higher in overweight and obese than normal weight subjects {6.6±3.8, 6.7±4.2 versus 5.6±2.9 µIU/mL, ( p<0.001 )}, with highest concentrations in severely obese than mildly and non-obese subjects {(7.4±5.6 versus 6.7±4.2 versus 6.05±3.0 µIU/mL ( p<0.001 , One-way Kruskal-Wallis). However, resistin showed no significant ( p>0.05 ) correlations to HOMA-IR, FI and obesity indices. The higher HOMA-IR found in overweight and obese than normal weight subjects (3.7±3.5, 2.9±2.4 vs. 2.1±0.4, p<0.001 ), was positively correlated to obesity and FI, which also increased from mild to severe BMI categories. Conclusion Higher resistin concentrations are found in severe obesity among non-diabetes black Africans, but its lack of correlation with insulin resistance and obesity indices may suggests possible interplay of other pro-inflammatory cytokines or hormones which may be evaluated in further studies.

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