Evidence that changes the way you practice Bipolar Disorder: Mania and depression explained

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Bipolar Disorder (BD) is characterised by alternating discrete episodes of depression and mania.1 Rational pharmacotherapy necessitates an appreciation of these different phases and of the possible underlying pathophysiology. A greater understanding of the pathogenesis of BD has boosted awareness of how anti-bipolar drugs work, and vice versa.2 This bidirectional relationship has amplified knowledge in both disciplines.

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