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Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children

Article scientifique 2020 Anglais

Résumé

OBJECTIVE: Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. METHOD: Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. RESULTS: Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. CONCLUSION: QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.

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Sanogo, B., Ouermi, A., Barro, M., Millogo, A., Ouattara, A., Nacro, B. (2020). Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children. https://doi.org/10.1371/journal.pone.0241789

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Auteur(s)

Bintou Sanogo Alain Saga Ouermi Makoura Barro A Millogo Ad Bafa Ibrahim Ouattara Boubacar Nacro

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