Dose-effect relationship of metaraminol before spinal anesthesia in preventing hypotension induced by spinal anesthesia in parturients undergoing cesarean section

Résumé

Abstract Objective: To study the dose-effect relationship of metaraminol in preventing hypotension induced by spinal anesthesia in parturients undergoing cesarean section. Methods: One hundred and twenty-five parturients undergoing elective cesarean sections were randomly divided into 5 groups (n=25 each), metaraminol groups (PM1, PM2, PM3, PM4 and PM5). Metaraminol 20, 30, 40, 50 and 60μg·min-1 were intravenously infused before spinal anesthesia. Effective prevention of hypotension was defined as the absence of hypotension during the period from the end of the administration of spinal anesthesia to the delivery of the fetus. The ED50, ED90, and 95% confidence intervals of metaraminol in preventing hypotension induced by spinal anesthesia were calculated by Probit analysis. Results: The ED50 and 95% confidence interval of metaraminol in preventing hypotension induced by spinal anesthesia were 46.52 (39.41-57.64) μg·min-1, and ED90 and 95% confidence interval were 97.10(77.17-157.49) μg·min-1. The incidence of hypotension and shivering decreased with the increase in the dose of metaraminol infused in the five groups (P<0.05). The incidence of reactive hypertension increased with the increase in the dose of metaraminol infused in the five groups (P<0.05). Conclusion: The ED50 and ED90 of metaraminol before spinal anesthesia in preventing spinal anesthesia-induced hypotension, in the patients undergoing cesarean section are 46.52 and 97.10μg·min-1, respectively.

Citer ce document

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0