Total Testosterone Concentration and Severity of Hirsutism in a Group of Hirsute Women of Yaoundé

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ABSTRACT Background. Hirsutism is the excessive terminal hair growth in androgen-dependent areas of the body in women, which grows in a typical male distribution pattern. This phenomenon results from simultaneous action of testosterone on the hair follicle and the sebaceous gland. The objective of this work was to establish a correlation between severity of hirsutism and testosterone levels in this group of women. Materials and Methods. We conducted a prospective descriptive cross-sectional study, setting at Yaounde central hospital in the endocrinology unit. Participants were recruited by convenience sampling. The Ferriman and Gallway score was used for clinical classification of hirsutism. We measured total plasma testosterone using enzyme immunoassay ELISA. Spearman test was used to assess correlation between the study parameters. Results. Our study population consisted of 69 women aged 18 to 48 years. Hirsutism was mild in 63.7% (44/69) of women; moderate in 36.2% (25/69) of women. No women had severe hirsutism. Mean testosterone was 1.36 ± 1.00 ng / mL: 91.7% (66/69) of women with testosterone greater than 0.6 ng / mL. There was a weak but not significant negative correlation between degree of hirsutism and plasma total testosterone concentration (r: -0.178, p: 0.138). Conclusion. In women with mild or moderate hirsutism, the degree of hirsutism does not reflect total testosterone levels. RESUME Introduction. L'hirsutisme est la croissance excessive des poils dans les zones du corps dependant des androgenes chez les femmes, qui se developpe dans un schema de distribution masculine typique. Ce phenomene resulte de l'action simultanee de la testosterone sur le follicule pileux et la glande sebacee. L'objectif de ce travail etait d'etablir une correlation entre la severite de l'hirsutisme et les niveaux de testosterone dans ce groupe de femmes. Materiels et methode. Nous avons mene une etude prospective descriptive transversale dans l'unite d'endocrinologie de l’hopital central de Yaounde. Les participantes ont ete recrutees par echantillonnage de convenance. Le score de Ferriman et Gallway a ete utilise pour la classification clinique de l'hirsutisme. Nous avons mesure la testosterone plasmatique totale en utilisant un test immuno-enzymatique ELISA. Le test de Spearman a ete utilise pour evaluer la correlation entre les parametres de l'etude. Resultats. Notre population d'etude etait composee de 69 femmes âgees de 18 a 48 ans. L'hirsutisme etait leger chez 63,7% (44/69) des femmes ; moderee chez 36,2% (25/69) des femmes. Aucune femme ne souffrait d'hirsutisme grave. La testosterone moyenne etait de 1,36 ± 1,00 ng / mL; 91,7% (66/69) des femmes ayant une testosterone superieure a 0,6 ng / ml. Il y avait une correlation negative faible mais non significative entre le degre d'hirsutisme et la concentration plasmatique totale de testosterone (r : -0,178, p: 0,138). Conclusion. En cas d’hirsutisme leger ou modere, le degre d'hirsutisme ne reflete pas les niveaux totaux de testosterone.

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