Editorial: Pharmacological actions of drugs in the brain: exploring the intricacies and potential therapeutic applications

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The brain's intricate and dynamic nature has made it a focal point of pharmacological research, with the goal of understanding how various drugs interact with its complex systems (Agid et al., 2007). This Research Topic, "Pharmacological Actions of Drugs in the Brain: Exploring the Intricacies and Potential Therapeutic Applications," brings together a diverse collection of 13 articles, each shedding light on different aspects of this field. Notably, this collection is part of a Research Topic dedicated to the Mediterranean Neuroscience Society Conference 2023, held in Tunis, Tunisia (MNS 2023). These studies explore the mechanisms by which drugs modulate brain activity and behavior, offering insights into potential therapeutic avenues for a range of neurological and psychiatric conditions. explore the neuroprotective effects of lutein, demonstrating its ability to inhibit glutamateinduced apoptosis in HT22 cells via the Nrf2/HO-1 signaling pathway. This study reinforces the potential of targeting oxidative stress pathways in developing therapies for neurodegenerative diseases. Together, these 13 articles not only deepen our understanding of the pharmacological actions of drugs in the brain, but also highlight the potential for developing new therapeutic strategies to address a range of neurological and psychiatric disorders. The insights gained from these studies are poised to inform future research and clinical practice, paving the way for more effective treatments and better patient outcomes.

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