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Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal

Article scientifique 2021 Anglais

Résumé

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.

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Ahouidi, A., Rodgers, M., Padane, A., Lèye, N., Mbow, M., Mboup, A., Diaw, P., Dia, A., Harris, B., Padane, Y., Lô, G., Meyer, T., Diédhiou, C., Diagne, D., Kâne, N., Cloherty, G., Mboup, S. (2021). Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal. https://doi.org/10.1038/s41598-021-02874-z

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Auteur(s)

Ambroise D. Ahouidi Mary A. Rodgers Abdou Padane Nafissatou Lèye Moustapha Mbow Aminata Mboup Papa Alassane Diaw Aminata Dia Barbara J. Harris Yacine Amet Dia Padane Gora Lô Todd Meyer Cyrille K. Diédhiou Diabou Diagne Ndèye Coumba Touré Kâne Gavin Cloherty Souleymane Mboup

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