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Outbreak of dengue fever in Ghana: The emergence of DENV-1 serotype

Article scientifique 2026 Anglais

Résumé

BACKGROUND: Dengue, a mosquito-borne virus continues to be a public health concern in the tropics and subtropical parts of Africa. Due to the increase of urbanization, climate change and trans-Atlantic trade, the transmitting vector, Aedes aegypti, has become prevalent hence the rapid growth of the disease, globally. In Ghana, there have been sporadic laboratory-confirmed cases of dengue reported over the years through surveillance activities. However, despite the detection of these cases, Ghana had never experienced a major outbreak (unlike its neighboring countries) until July 2024. METHODS: During this outbreak, a total of 1471 suspected dengue fever specimen received from various health facilities in Ghana in NMIMR for molecular diagnostic testing using a RT-qPCR assay for dengue, chikungunya and Zika viruses and selected positives sequenced using Illumina Next Generation Sequencing. RESULTS: Dengue fever virus RNA was detected from 206 samples and serotyped as DENV-1 with one DENV-3 coinfection. Thirty-nine genomes were successfully generated after sequencing and phylogenetic analysis of DENV-1 strains revealed two main clusters with AFI isolates in Ghana and isolates from other West African countries (Côte d'Ivoire, Burkina Faso, Benin, and Senegal) circulating between 2017-2019. In 2023, DENV-1 was frequently isolated which could account for it being the predominant serotype transmitted in the recent outbreak. CONCLUSION: The outbreak response and the case management procedures deployed by the health authorities during this outbreak were swift and was enough to prevent a fatal difficult-to-control situation. With the absence of a widely accepted commercialized vaccine and treatment for dengue fever, there is a need to enhance surveillance activities and control the vectors which can transmit DENV in-country to curb the occurrence of outbreaks.

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Pratt, D., Awuku-Larbi, Y., Ofori, M., Agbodzi, B., Wiley, J., Mante, A., Kumordjie, S., Eshun, M., Bour, S., Enimil, N., Acquah-Amaning, J., Ketorwoley, P., Boapea, M., Nutakor, D., Salisu, M., Stephens, G., Boateng, E., Adjandeh, T., Koomson, J., Laryea, D., Asiedu‐Bekoe, F., Kuma‐Aboagye, P., Avevor, P., Guracha, A., Ohene, S., Sanders, T., Wiley, M., Bonney, J. (2026). Outbreak of dengue fever in Ghana: The emergence of DENV-1 serotype. https://doi.org/10.1371/journal.pntd.0014248

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Auteur(s)

Deborah Pratt Yaw Awuku-Larbi Magdalene Sarah Nketia Ofori Bright Agbodzi Jessica Wiley Ama Amankwa Ofosua Mante Selassie Kumordjie Miriam Eshun Stella Bour Nancy Enimil Juliana Acquah-Amaning Prince Ketorwoley Maame Serwaa Boapea David Nutakor Musah Salisu Gertrude Stephens Emmanuel Boateng Tracy Adjandeh Joel Koomson Dennis Laryea Franklin Asiedu‐Bekoe Patrick Kuma‐Aboagye Patrick Avevor Argata Guracha Sally-Ann Ohene Terrel Sanders Michael Wiley Joseph Humphrey Kofi Bonney

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