Sero-Prevalence and Risk Factors of Hepatitis C Virus Infection Among Children Diagnosed With Cancer in Lagos Nigeria.

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Abstract Introduction: HCV is a blood borne viral infection transmitted mainly via blood and blood product transfusion. Children diagnosed with cancers are especially in the high-risk group for infection with blood transmissible infections like HCV because of their dependence on blood and blood product. Children with cancer are also exposed to unwholesome practice like scarification marks. Also children with cancer because of their immunocompromised state lack the ability effectively clear HCV after an acute infection, there are therefore very likely to have chronic infections.Because of the above reason it became necessary to determine the prevalence and risk factors for HCV infection among children with cancer at Lagos .Methods: We designed a descriptive cross-sectional study conducted over a 12 months period at the Oncology ward and outpatient clinics of LUTH.Result: 50 children with cancers were recruited age range 7 months and 17 years. Ninety percent of them has been exposed to blood transfusion while 32% and 18% of them has had surgery and scarification marks respectively. The most diagnosed cancer was ALL with 44%. And 82% of the subjects were on chemotherapy at the time of recruitment. The sero-prevalence of HCV infection among those with cancer was 0%.Conclusion: The sero-prevalence of HCV infection was zero percent despite significant exposure to blood transfusion and other risk factors.

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