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Vitamin D deficiency and its association with iron deficiency in African children

Article scientifique 2021 Anglais

Résumé

Abstract Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism. Although vitamin D and iron deficiency are highly prevalent globally little is known about their interactions in Africa. To evaluate associations between vitamin D and iron status we measured markers of iron status, inflammation, malaria parasitemia and 25-hydroxyvitamin D (25(OH)D) concentrations in 4509 children aged 0.3 months to 8 years living in Kenya, Uganda, Burkina Faso, The Gambia and South Africa. Prevalence of iron deficiency was 35.1%, and preva- lence of vitamin D deficiency was 0.6% and 7.8% as defined by 25(OH)D concentrations of <30 nmol/L and <50 nmol/L respectively. Children with 25(OH)D concentrations of <50 nmol/L had a 98% increased risk of iron deficiency (OR 1.98 [95% CI 1.52, 2.58]) compared to those with 25(OH)D concentrations >75 nmol/L. 25(OH)D concentrations variably influenced individual markers of iron status. Inflammation interacted with 25(OH)D concentrations to predict ferritin levels. The link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies in African children.

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Mogire, R., Muriuki, J., Morovat, A., Mentzer, A., Webb, E., Kimita, W., Ndungu, F., Macharia, A., Cutland, C., Sirima, S., Diarra, A., Tiono, A., Lule, S., Madhi, S., Prentice, A., Bejon, P., Pettifor, J., Elliott, A., Adeyemo, A., Williams, T., Atkinson, S. (2021). Vitamin D deficiency and its association with iron deficiency in African children. https://doi.org/10.1101/2021.07.14.21260499

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Auteur(s)

Reagan M. Mogire John M. Muriuki Alireza Morovat Alexander J. Mentzer Emily L. Webb Wandia Kimita Francis M. Ndungu Alex Macharia Clare Cutland Sodiomon B. Sirima Amidou Diarra Alfred B. Tiono Swaib A. Lule Shabir A. Madhi Andrew M. Prentice Philip Bejon John Μ. Pettifor Alison M. Elliott Adebowale Adeyemo Thomas N. Williams Sarah H. Atkinson

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