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Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

Article scientifique 2021 Anglais

Résumé

Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.

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Ahuno, S., Doebley, A., Ahearn, T., Yarney, J., Titiloye, N., Hamel, N., Adjei, E., Clegg‐Lamptey, J., Edusei, L., Awuah, B., Song, X., Vanderpuye, V., Abubakar, M., Duggan, M., Stover, D., Nyarko, K., Bartlett, J., Aitpillah, F., Ansong, D., Gardner, K., Boateng, F., Bowcock, A., Caldas, C., Foulkes, W., Wiafe, S., Wiafe‐Addai, B., García‐Closas, M., Kwarteng, A., Ha, G., Figueroa, J., Polak, P., Adjei, R., Afriyie, L., Adjei, A., Dedey, F., Okyne, V., Oti, N., Tay, E., Kenu, A., Ekpedzor, O., Alcpaloo, M., Boakye, I., Arhin, B., Assimah, E., Ka-Chungu, S., Oppong, J., Osei‐Bonsu, E., Frempong, M., Abaidoo, E., Mensah, B., Amanama, S., Agyapong, P., Agyei, T., Opoku, R., Gyimah, K., Newman, L., Brinton, L., Palakal, M., Thistle, J., Brotzman, M., Niwa, S., Singh, U., Truelove, A., Biritwum, R. (2021). Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa. https://doi.org/10.1038/s41698-021-00219-7

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Auteur(s)

Samuel Terkper Ahuno Anna-Lisa Doebley Thomas U. Ahearn Joel Yarney Nicholas Titiloye Nancy Hamel Ernest Adjei Joe‐Nat Clegg‐Lamptey Lawrence Edusei Baffour Awuah Xiaoyu Song Verna Vanderpuye Mustapha Abubakar Máire A. Duggan Daniel G. Stover Kofi Nyarko John M.S. Bartlett Francis Aitpillah Daniel Ansong Kevin Gardner Felix Andy Boateng A. Bowcock Carlos Caldas William D. Foulkes Seth Wiafe Beatrice Wiafe‐Addai Montserrat García‐Closas Alexander Kwarteng Gavin Ha Jonine D. Figueroa Paz Polak Robertson Adjei Lucy Afriyie Anthony Adjei Florence Dedey Victoria Okyne Naomi Ohene Oti Evelyn Tay Angela Kenu Obed Ekpedzor Marion Alcpaloo Isaac Boakye Bernard Arhin Emmanuel Assimah Samuel Mingyigilougu Apewe Ka-Chungu Joseph K. Oppong Ernest Osei‐Bonsu Margaret Frempong Emma Brew Abaidoo Bridget Nortey Mensah Samuel Amanama Prince Agyapong Thomas Ansong Agyei Richard Opoku Kofi Owusu Gyimah Lisa Newman Louise A. Brinton Maya Palakal Jake E. Thistle Michelle Brotzman Shelley Niwa Usha Singh Ann Truelove Richard Biritwum

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