Musa Acuminata Wastes as New Potential source of Anti-ulcerative Colitis Agents : Pharmacological and Metabolomics Profiles

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Abstract Musa acuminata is a popular fruit in the world. Non-food parts of the plant have been investigated for their antioxidant and anti-ulcerative colitis activity. Metabolomic approaches was found to be informative as a screening tool. It discovered different metabolites depending on statistical analysis. The antioxidant activity content was measured by colorimetric method. Seventy six investigated metabolites were observed. The identities of some of these markers were confirmed based on their MS2 fragmentation and NMR spectroscopy. These include: Cinnamic acid and its dimer 2-hydroxy-4-(4-methoxyphenyl)-1H-phenalen-1-one beside Gallic acid and flavonoids; Quercetin, Quercetin-3-O-β-D-glucoside, Luteolin-7-O-β-D-glucopyranoside. The leaves, pseudostem and fruit peels extracts were tested for their safety and their antiUlcerative-colitis efficacy in rats. Rats were classified into:Normal, Positive, prednisolone reference group , Musa extracts pretreated groups(250-500mg/kg) for two weeks followed by induction of Ulcerative-colitis by per-rectal infusion of 8% acetic acid. Macroscopic and microscopic examination were done. Inflammatory markers (ANCA, CRP and Ilβ6) were measured in sera. The extracts showed good antioxidant and anti-inflammatory activities as they ameliorated macroscopic and microscopic signs of Ulcerativecolitis and lowered the inflammatory markers compared to untreated group. Musa wastes can be a potential source of bioactive metabolites for industrial use and future employment as promising anti-Ulcerativecolitis food supplements.

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