Peer Review Report For: The Five-years Overall Survival and Recurrence Free Survival of Neoadjuvant Systemic Therapy in Breast Cancer Sudanese Patients: A Retrospective Comparative study [version 1; peer review: 1 approved]

Résumé

Background Breast cancer (BC) is a leading cause of cancer-related mortality among women worldwide. The role of neoadjuvant chemotherapy (NAC) in improving clinical outcomes for breast cancer patients has gained significant attention; however, its impact on long-term survival and recurrence rates remains under investigation. Thus, we evaluated the effectiveness of NAC on metastasis, recurrence rates, and overall survival in BC patients. Statistical analyses, including Chi-square tests and Kaplan-Meier survival analysis, were employed to assess differences between groups. Methods In this retrospective study, 46 Sudanese patients with locally advanced BC were consecutively collected attending Alsharif Specialized Hospital during the period from 2015 to 2016, comprising 28 patients who received NAC (case group) and 18 patients who underwent upfront surgery (control group). Data regarding demographics, histological types, treatment regimens, prognostic markers, survival, recurrence and metastasis were collected Results Most of patients in both groups were > 40 years old. Invasive ductal carcinoma (IDC) was the predominant histological type observed. Notably, the metastasis rate was lower in the case group than in the control group (n=6; 21.4% vs. n=9; 50%, P = 0.043). However, the recurrence rates and overall survival did not differ significantly between the two groups (P = 0.353 and P = 0.454, respectively). The estimated mean survival time was 74.1 months for the case group compared to 82.0 months for the control group, but without significant difference (log-rank P = 0.973). Conclusion While NAC appears to reduce metastasis rates in breast cancer patients, it does not significantly impact recurrence rates or overall survival. These results underscore the need for further research to explore additional factors that influence long-term outcomes of breast cancer management.

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