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t(1;4) translocation in a child with acute lymphoblastic leukemia: a case report

Article scientifique 2023 Anglais

Résumé

BACKGROUND: Acute lymphoblastic leukemia is the most common childhood cancer, with an 80% frequency in children between 1 and 10 years old. The outcome and prognosis of acute lymphoblastic leukemia in children depends on various factors, such as age, clinical and biological features, and cytogenetic factors. CASE PRESENTATION: We report the case of a pediatric patient, a 4-year-old Moroccan female who was referred to the Hematology and Oncology Department of 20 August 1953 Hospital in Casablanca and diagnosed with B-cell acute lymphoblastic leukemia associated with a rare genetic chromosomal abnormality. CONCLUSION: Translocation (1;4)(p21;p15) is a relatively rare chromosomal abnormality found in human leukemia and was never described isolated in pediatric B-cell acute lymphoblastic leukemia patients. It showed a good evolution by complete remission and recovery of this patient after receiving all chemotherapy and after 8 years of follow-up.

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Mahdaoui, C., Hda, N., Oukkache, B., Dehbi, H., Khoubila, N., Madani, A., Cherkaoui, S. (2023). t(1;4) translocation in a child with acute lymphoblastic leukemia: a case report. https://doi.org/10.1186/s13256-023-04270-9

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Auteur(s)

Chaimae El Mahdaoui Nezha Hda Bouchra Oukkache Hind Dehbi Nisrine Khoubila Abdellah Madani Siham Cherkaoui

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