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Serologic evidence of orthomarburgviruses and an orthoebolavirus in frugivorous Malagasy bats

Article scientifique 2025 Anglais

Résumé

Recent outbreaks of Marburg virus disease in regions of sub-Saharan Africa without prior record such as Ghana, Tanzania, Equatorial Guinea, and Rwanda challenge the current understanding of areas at-risk for filovirus spillover. The orthomarburgvirus host Rousettus aegyptiacus exists in these regions, and has a sister species, Rousettus madagascariensis, native only to the island of Madagascar. We expand on previous surveillance of frugivorous bats in Madagascar, and detect seroreactivity against an orthoebolavirus antigenically-related to Bundibugyo virus at 1.50-5.06% seroprevalence in Rousettus madagascariensis. Notably, we identify R. madagascariensis as an orthomarburgvirus-host species of interest in Madagascar, the first record of this virus genus on the island. We document seroprevalences of 15.36-29.78% for Ravn virus and 12.55-33.33% for Marburg virus in R. madagascariensis. These findings will guide future biosurveillance efforts to assess filovirus spillover risk in Madagascar.

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Rekedal, M., Ruhs, E., Ranaivoson, H., Mittal, N., Sterling, S., Kettenburg, G., Andrianiaina, A., Andry, S., Yan, L., Lehrer, A., Héraud, J., Lacoste, V., Dussart, P., Brook, C., Laing, E. (2025). Serologic evidence of orthomarburgviruses and an orthoebolavirus in frugivorous Malagasy bats. https://doi.org/10.1186/s42522-025-00178-0

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Auteur(s)

Marana S. Rekedal Emily Cornelius Ruhs Hafaliana Christian Ranaivoson Neil Mittal Spencer L. Sterling Gwenddolen Kettenburg Angelo Andrianiaina Santino Andry Lianying Yan Axel T. Lehrer Jean‐Michel Héraud Vincent Lacoste Philippe Dussart Cara E. Brook Eric D. Laing

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