Accès ouvert

In vivo anti-tumor effect of Egyptian scorpion Leiurus quinquestriatus venom in Ehrlich ascites carcinomabearing mice

Article scientifique 2023 Anglais

Résumé

Purpose: To investigate the anti-tumor efficacy of scorpion Leiurus quinquestriatus venom (LQV) in Ehrlich ascites carcinoma (EAC) mouse model.Methods: Mice were divided into 4 groups (n = 8), with Group 1 as negative control. Groups 2 to 4 mice were inoculated with EAC cells (1 x 106/mouse) intraperitoneally (ip). Group 2 mice were untreated while groups 3 and 4 mice were injected with 2 mg/kg of cisplatin (Cis) and 0.025 mg/kg of LQV ip, respectively, for 7 days. Tumor profile, as well as hematological and biochemical analyses were carried out.Results: Tumor volume and tumor cell counts decreased significantly (p < 0.05) following LQV treatment. Also, LQV potentiated necrosis, apoptosis and arrested tumor cells in the G0 and S-phases. Furthermore, it upregulated apoptotic-related gene (Bax and caspase-3) expressions and down-regulated anti-apoptotic gene (bcl-2) expression in EAC cells (p < 0.05).Conclusion: LQV has potential anti-tumor activity against EAC cells in mouse models. Therefore, it should be further investigated in vivo as an anti-tumor agent.

Citer ce document

Salama, W., El-Naggar, S., Alrashdi, B. (2023). In vivo anti-tumor effect of Egyptian scorpion Leiurus quinquestriatus venom in Ehrlich ascites carcinomabearing mice. https://doi.org/10.4314/tjpr.v22i8.15

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

Wesam M. Salama Sabry El-Naggar Barakat M. Alrashdi

Statistiques

Consultations : 1

Téléchargements : 0