Incidence of Epilepsy among elderly Sudanese patients with Alzheimer’s disease: A prospective cohort study on 480 patients, Khartoum, Sudan, 2019

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Abstract Background: An increased prevalence of epilepsy had been documented with dementia. Alzheimer’s disease and epilepsy often coexist. Objective: The aim of this study to assess incidence rates of epilepsy among Sudanese patients with Alzheimer’s disease. Methods: This is a prospective cohort study. We followed 480 patients aged more than 65 years with diagnosis of Alzheimer’s disease between May 2006 and May 2019 looking for coexist epilepsy. Results: Regarding Alzheimer’s disease female were affected more than male (60%). 10% of our patients have epilepsy. Generalize epilepsy was the most common type (62%). Epilepsy was more common with late onset Alzheimer’s disease. Abnormal EEG was detected in 20% of our studied group. Abnormal Brain MRI in form of cerebral atrophy was observed in 60 % of patients with Alzheimer’s disease and epilepsy. Conclusion: Patients with Alzheimer’s disease have an increased risk of developing epilepsy. There is strong relation between disease duration and development of epilepsy.

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