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A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017

Article scientifique 2018 Anglais

Résumé

BACKGROUND: In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail. FINDING: The full-length genome sequence of an HEV-2 strain (NG/17-0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17-0500 belongs to HEV subtype 2b (HEV-2b). CONCLUSIONS: We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.

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Wang, B., Akanbi, O., Harms, D., Adesina, O., Osundare, F., Naidoo, D., Deveaux, I., Ogundiran, O., Ugochukwu, U., Mba, N., Ihekweazu, C., Bock, C. (2018). A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017. https://doi.org/10.1186/s12985-018-1082-8

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Auteur(s)

Bo Wang Olusola Anuoluwapo Akanbi Dominik Harms Olufisayo Adeyemi Adesina Folakemi Abiodun Osundare Dhamari Naidoo Isabel Deveaux Opeayo Ogundiran Uzoma Ugochukwu Nwando Mba Chikwe Ihekweazu C.–Thomas Bock

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