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Synthesis and Characterization of MoS 2 Nanoflowers Decorated Amino Cellulose Derivatives: An Innovative Approach for Anticancer Therapeutics

Article scientifique 2023 Anglais

Résumé

Abstract Microcrystalline cellulose (MCC) was modified to amino cellulose (AC) derivatives, 6-deoxy-6-hydrazide cellulose, 6-deoxy-6-(N, N-diethyl) amine cellulose, and 6-deoxy-6-diethyltriamine cellulose (C-Hyd, C-DEA, and C-DETA). AC’s were used as supporting material for the MoS2 Nanoflowers (NFs) for the development of nanocomposites as cancer therapeutics. ACs-MoS2 nanocomposites were analyzed by using spectroscopy, X-ray diffraction (XRD), Scanning Electron Microscopy (SEM)-EXS, and Zeta potential. MoS2 NF loading, swelling, and degradation rate of ACs-MoS2 nanocomposites have been investigated. ACs-MoS2 nanocomposites were analyzed against four cancer cell lines NIH3T3, B16F10, MDA-MB-231, and MCF-7 cell lines by using presto blue and LIVE/DEAD staining. Cell viability assay and fluorescence microscopy against four cell lines revealed that all AC’s-MoS2 nanocomposites with 5wt% MoS2 showed selective cytotoxicity for cancer cell lines as compared to normal fibroblast cell lines. Our findings revealed that amino cellulose derivatives loaded with MoS2 could be efficient candidates for skin and breast cancer therapy.

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Nazir, F., Khan, A., Ashraf, I., Lughmani, F., Rafiq, B., Iqbal, M. (2023). Synthesis and Characterization of MoS 2 Nanoflowers Decorated Amino Cellulose Derivatives: An Innovative Approach for Anticancer Therapeutics. https://doi.org/10.21203/rs.3.rs-2366553/v1

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Farzana Nazir Areesha Khan Iffat Ashraf Faiza Lughmani Bushra Rafiq Mudassir Iqbal

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