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APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson’s disease

Article scientifique 2022 Anglais

Résumé

The relationship between APOE polymorphisms and Parkinson's disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. APOE genotype and allele frequencies did not differ between PD and controls (p > 0.05). No allelic or genotypic association was observed between APOE and age at onset of PD. In PD, APOE ε4/ε4 conferred a two-fold risk of cognitive impairment compared to one or no ε4 (HR: 2.09 (95% CI: 1.13-3.89; p = 0.02)), while APOE ε2 was associated with modest protection against cognitive impairment (HR: 0.41 (95% CI 0.19-0.99, p = 0.02)). Of 773 PD with motor phenotype and APOE characterized, tremor-dominant (TD) phenotype predominated significantly in ε2 carriers (87/135, 64.4%) compared to 22.2% in persons with postural instability/gait difficulty (PIGD) (30/135) and 13.3% in indeterminate (ID) (18/135, 13.3%) (p = 0.037). Although the frequency of the TD phenotype was highest in homozygous ε2 carriers (85.7%), the distribution of motor phenotypes across the six genotypes did not differ significantly (p = 0.18). Altogether, our findings support previous studies in other ethnicities, implying a role for APOE ε4 and ε2 as risk and protective factors, respectively, for cognitive impairment in PD.

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Okubadejo, N., Okunoye, O., Ojo, O., Arabambi, B., Akinyemi, R., Osaigbovo, G., Abubakar, S., Iwuozo, E., Wahab, K., Agabi, O., Agulanna, U., Imarhiagbe, F., Abiodun, O., Achoru, C., Adebowale, A., Adeniji, O., Akpekpe, J., Ali, M., Ani‐Osheku, I., Arigbodi, O., Balarabe, S., Bello, A., Ekenze, O., Erameh, C., Farombi, T., Fawale, B., Komolafe, M., Nwani, P., Nwazor, E., Nyandaiti, Y., Obehighe, E., Obiabo, Y., Odeniyi, O., Odiase, F., Ojini, F., Onwuegbuzie, G., Osemwegie, N., Oshinaike, O., Otubogun, F., Oyakhire, S., Taiwo, F., Williams, U., Ozomma, S., Zubair, Y., Hernández, D., Bandrés‐Ciga, S., Blauwendraat, C., Singleton, A., Houlden, H., Hardy, J., Rizig, M. (2022). APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson’s disease. https://doi.org/10.1038/s41531-022-00411-x

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Auteur(s)

Njideka Okubadejo Olaitan Okunoye Oluwadamilola O. Ojo Babawale Arabambi Rufus Akinyemi Godwin Osaigbovo Sani Abubakar Emmanuel Iwuozo Kolawole Wahab Osigwe Agabi Uchechi Agulanna Frank Imarhiagbe Oladunni Abiodun Charles Achoru Akintunde Adebowale Olaleye Adeniji John E. Akpekpe Mohammed Ali Ifeyinwa Ani‐Osheku Ohwotemu Arigbodi Salisu A. Balarabe Abiodun Bello Oluchi Ekenze Cyril Erameh Temitope Farombi Bimbo Fawale Morenikeji Komolafe Paul Nwani Ernest Nwazor Yakub Nyandaiti Emmanuel E. Obehighe Yahaya Obiabo Olanike Odeniyi Francis Odiase FI Ojini Gerald Onwuegbuzie Nosakhare Osemwegie Olajumoke Oshinaike Folajimi Otubogun Shyngle Oyakhire Funmilola Taiwo Uduak Williams Simon Ozomma Yusuf Zubair Dena Hernández Sara Bandrés‐Ciga Cornelis Blauwendraat Andrew Singleton Henry Houlden John Hardy Mie Rizig

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