Therapeutic potential of methanol extracts of Calocybe indica (mushroom) on cadmium chloride-induced hepato-renal toxicity in rats

Résumé

Purpose: To investigate the efficacy of Calocybe indica extract (CIE) in alleviating liver and kidney toxicity caused by cadmium chloride (CdCl₂) in rats. Methods: Six groups of five rats each were used in this study. Group A was the control while groups B to F received 3 mg/kg CdCl2 subcutaneously. Group B was induced with CdCl2 alone for 21 days. Orally, 100 mg/kg of vitamin C, and 200, 400, and 800 mg/kg of CIE were used to treat groups C, D, E, and F respectively. Data were analyzed using Statistical Packages for Social Sciences (SPSS), and results were presented as mean ± standard deviation (SD). Results: Group B had higher liver and kidney weights, and lower body weight compared to control group (p ≥ 0.05). Treatment with CIE increased body weight in CdCl2-induced rats lowers serum levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and total bilirubin, improves liver and kidney function, and significantly increased superoxide dismutase (SOD) activity (p < 0.05). Conclusion: Calocybe indica (CIE) extract increases body weight, lowers serum levels of liver enzymes, improves kidney function and significantly lowers SOD activity. Calocybe indica extract may serve as a potential pharmacological candidate or therapeutic alternative for managing hepato-renal injuries. Subsequent molecular studies to ascertain its bioactive compounds will pave the way for the discovery of drug candidates.

Citer ce document

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0