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Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study

Article scientifique 2022 Anglais

Résumé

There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers-total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides-with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.

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Gupta, A., Saraiya, V., Deveaux, A., Oyekunle, T., Jackson, K., Salako, O., Daramola, A., Hall, A., Alatise, O., Ogun, G., Adeniyi, A., Ayandipo, O., Olajide, T., Olasehinde, O., Arowolo, O., Adisa, A., Afuwape, O., Olusanya, A., Adegoke, A., Tollefsbol, T., Arnett, D., Muehlbauer, M., Newgard, C., Ajayi, S., Raji, Y., Olanrewaju, T., Osafo, C., Ulasi, I., Asinobi, A., Winkler, C., Burke, D., Arogundade, F., Ekem, I., Plange‐Rhule, J., Mamven, M., Mate-kole, M., Amodu, O., Cooper, R., Antwi, S., Adeyemo, A., Ilori, T., Adabayeri, V., Nyarko, A., Ghansah, A., Amos-Abanyie, E., Akyaw, P., Kimmel, P., Salako, B., Parekh, R., Tayo, B., Gbadegesin, R., Boehnke, M., Lyons, R., Brosius, F., Clauw, D., Adindu, C., Bewaji, C., Tannor, E., Okyere, P., Ijoma, C., Tiffin, N., Gamiedien, J., Hildebrandt, F., Odenigbo, C., Jisieike-Onuigbo, N., Modebe, I., Abdu, A., Obiagwu, P., Okoye, O., Solarin, A., Amira, T., Esezobor, C., Makusidi, M., Saraf, S., Gordeuk, V., Ashuntangtang, G., Guenkam, G., Kazi, F., Adedoyin, O., McCullough, M., Nourse, P., Okafor, U., Anígilájé, E., Ikpebe, P., Odetunde, T., Mbanefo, N., Olowu, W., Tindana, P., Awobusuyi, O., Ogedegbe, O., Olabisi, O., Skorecki, K., Adebowale, A., Kretzler, M., Hodgin, J., Adu, D., Ojo, A., Boima, V., Akinyemiju, T. (2022). Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study. https://doi.org/10.1038/s41598-022-13740-x

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Auteur(s)

Anjali Gupta Veeral Saraiya April Deveaux Taofik Oyekunle Klarissa D. Jackson Omolola Salako Adetola Daramola Allison Hall Olusegun Isaac Alatise Gabriel Olabiyi Ogun Adewale Adeniyi Omobolaji Ayandipo Thomas Olajide Olalekan Olasehinde Olukayode Arowolo Adewale Adisa Oludolapo Afuwape Aralola Olusanya Aderemi Adegoke Trygve O. Tollefsbol Donna K. Arnett Michael J. Muehlbauer Christopher B. Newgard Samuel Ajayi Yemi Raheem Raji Timothy O. Olanrewaju Charlotte Osafo Ifeoma Ulasi Adanze Onyenonachi Asinobi Cheryl A. Winkler David Burke Fatiu A. Arogundade Ivy Ekem Jacob Plange‐Rhule Manmak Mamven Michael Mate-kole Olukemi K. Amodu Richard G. Cooper Sampson Antwi Adebowale Adeyemo Titilayo O. Ilori Victoria Adabayeri Alexander K. Nyarko Anita Ghansah Ernestine Kubi Amos-Abanyie Priscilla Abena Akyaw Paul L. Kimmel Babatunde Salako Rulan S. Parekh Bamidele O. Tayo Rasheed Gbadegesin Michael Boehnke Robert Lyons Frank C. Brosius Daniel J. Clauw Chijioke Adindu Clement O. Bewaji Elliot Koranteng Tannor Perditer Okyere Chuba Ijoma Nicki Tiffin Junaid Gamiedien Friedhelm Hildebrandt Charles Odenigbo Nonyelun Jisieike-Onuigbo I Modebe Aliyu Abdu Patience Obiagwu Ogochukwu Okoye Adaobi Solarin Toyin Amira Christopher Imokhuede Esezobor Muhammad Makusidi Santosh L. Saraf Victor R. Gordeuk Gloria Ashuntangtang Georgette Guenkam Folefack Kazi Olanrewaju T. Adedoyin Mignon McCullough Peter Nourse Uche Okafor Emmanuel Adémólá Anígilájé Patrick Ikpebe Tola Odetunde Ngozi R Mbanefo Wasiu A. Olowu Paulina Tindana Olubenga Awobusuyi Olugbenga Ogedegbe Opeyemi A. Olabisi Karl Skorecki Ademola Adebowale Matthias Kretzler Jeffrey B. Hodgin Dwomoa Adu Akinlolu Ojo Vincent Boima Tomi Akinyemiju

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