Predicting cosolvents, surfactants and electrolytes as potential transdermal delivery enhancers of pantoprazole
Résumé
Purpose: To predict cosolvents, surfactants, and electrolytes as potential enhancers of pantoprazole transdermal delivery by examining their effects on the drug's coefficient of partition. Methods: At room temperature, the shake flask method was used in a chloroform-water system. The percent concentrations (% w/v) utilized in the study range from 0.0 - 25.0; 0.0 - 0.5 and 0.0 - 1.0 for cosolvents (glycerol, ethanol, propylene glycol, and polyethylene glycol 400); surfactants (Tween 20, Tween 80, sodium lauryl sulfate, and cetrimide); and electrolytes (NaCl, KCl, MgCl2, CaCl2, CdCl2, Na2SO4, K2SO4, MgSO4, AlCl3, and CoCl3), respectively. Established mathematical equations were utilized to calculate transdermal parameters. Results: Cosolvents, surfactants, and electrolytes reduced the logarithm partition coefficient of pantoprazole in comparison with control (distilled water). A significant difference (p < 0.05) occurred in the partition coefficient data of the drug between control and the vehicles/electrolytes investigated. Linear relationship was established between the logarithm partition coefficient and the logarithm estimated permeability coefficient of pantoprazole. Conclusion: Cosolvents, surfactants and electrolytes used are not to be considered potential transdermal delivery enhancers of pantoprazole.
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