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Resistance profiles, virulence and antimicrobial resistance genes of XDR S. Enteritidis and S. Typhimurium

Article scientifique 2023 Anglais

Résumé

Abstract Avian salmonellosis is concomitant with high financial crises in the poultry industry as well as food-borne illness in man. The present study is designed to investigate the emergence ofSalmonellaEnteritidis andSalmonellaTyphimurium in diseased broilers, resistance profiles, and monitoring virulence and antibiotic resistance genes. Consequently, 450 samples (cloacal swabs, liver, and spleen) were collected from 150 diseased birds from different farms in Giza Governorate, Egypt. Subsequently, the bacteriological examination was done. Afterward, the obtainedSalmonellaisolates were tested for serogrouping, antibiogram, PCR monitoring of virulence (invA,stn,hilA, andpefA), and antimicrobial resistance genes (blaTEM,blaCTX-M,blaNDM,ermA,sul1,tetA, andaadA1). The total prevalence of Salmonellain the examined diseased broilers was 9.3%, and the highest prevalence was noticed in cloacal swabs. Among the recovered Salmonella isolates (n = 35), 20 serovars were recognized as S. Enteritidis and 15 serovars were identified as S. Typhimurium. Almost 60% of the retrieved S. Enteritidis serovars were extensively drug-resistant (XDR) to seven antimicrobial classes and inherited sul1,blaTEM,tetA,blaCTX-M,ereA, andaadA1 genes. Likewise, 25% of the recovered S.Enteritidis serovars were multidrug-resistant (MDR) to six classes and havesul1,blaTEM, tetA,blaCTX-M, andereA resistance genes. Also, 66.7% of the retrieved S. Typhimurium serovars were XDR to seven classes and have sul1, blaTEM,tetA,blaCTX-M,ereA, andaadA1 genes. Succinctly, this report underlined the reemergence of XDR S. Typhimurium and S. Enteritidis in broiler chickens. Meropenem and norfloxacin exposed a hopeful antimicrobial activity toward the re-emerging XDR S. Typhimurium and S. Enteritidis in broilers. Moreover, the recurrence of these XDRSalmonellastrains poses a potential public health threat.

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Algammal, A., El-Tarabili, R., El‐Ghany, W., Almanzalawi, E., Alqahtani, T., Ghabban, H., Alotaibi, A., Al-Atfeehy, N., Abosleima, N., Hetta, ‏., Badawy, G. (2023). Resistance profiles, virulence and antimicrobial resistance genes of XDR S. Enteritidis and S. Typhimurium. https://doi.org/10.1186/s13568-023-01615-x

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Auteur(s)

Abdelazeem M. Algammal Reham M. El-Tarabili Wafaa A. Abd El‐Ghany Enas A. Almanzalawi Tahani M. Alqahtani Hanaa Ghabban Amenah S. Alotaibi Nayera M. Al-Atfeehy Naira M. Abosleima ‏Helal F. Hetta Ghada A. Badawy

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