Accès ouvert

SARS-Cov 2 infection and anti-tuberculosis immunity: temporal association or real protective role?

Article scientifique 2021 Anglais

Résumé

Abstract Introduction: According to the literature consulted to date, there is epidemiological heterogeneity of covid 19 between countries depending on their vaccination policy, in particular BCG vaccination. These findings have led to several hypotheses, including the protective role of immunity induced by the BCG tuberculosis vaccine against Covid-19 infection. The immunity induced by the BCG vaccine significantly increases the secretion of pro-inflammatory cytokines, in particular IL-1B, which has been shown to play an essential role in antiviral immunity. This cross-immunity, although not specific, if highlighted, is a real providence that must be taken advantage of in the face of this pandemic. The main objective of this study is to rule out or confirm that anti-tuberculosis immunity protects against SARS-COV 2 in our context. Materiel and methods: Two groups will be compared: cases infected with the virus and controls who have never been infected with the virus. Both case and control groups will undergo a tuberculin skin test: the intra dermal tuberculin reaction (IDR). Results: We found that our control group had a high IDR immunity value, with an IDR tuberculin positive percentage of 67.2%. This suggests that immunity to IDR is a protective factor against coronavirus disease. Conclusion: The hypothesis of nonspecific anti-tuberculosis protection deserves further verification studies; it would have large positive repercussions for developing countries.

Citer ce document

Hammi, S., MYRIEM, B., Najdi, A., RAJAE, C., KARIMA, R., Eddine, B., Benamor, J., FATEMA, E., SOUMIYA, E., MOHAMMED, M., RACHID, I., MOURABAIT, N., Kaissi, O., Zerrouki, A., GROURINDA, A., Bousgheiri, F., BELAFKI, H., MHAMED, H., MOHAMED, A. (2021). SARS-Cov 2 infection and anti-tuberculosis immunity: temporal association or real protective role?. https://doi.org/10.21203/rs.3.rs-1129122/v2

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Sanaa Hammi BOURKIA MYRIEM Adil Najdi CHAHBOUNE RAJAE RISSOUL KARIMA Bourkadi Jamal Eddine J. Benamor EL BOUZOUIKI FATEMA EL BACHIRI SOUMIYA MOUMKIN MOHAMMED ISMAILI RACHID NADIRA MOURABAIT Ouafae Kaissi Asmae Zerrouki ADIL GROURINDA F Bousgheiri HASSANA BELAFKI HARIF MHAMED AHALAT MOHAMED

Statistiques

Consultations : 1

Téléchargements : 0