Electrospun Manuka Honey@PVP nanofibers enclosing Chitosan-Titanate for Highly Effective Wound Healing

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Abstract Abstract The major challenge in skin tissue engineering is the creation of physically and functionally suitable extracellular matrix (ECM) scaffolds. Inspired by ECM macromolecular components, we suggest a new hybrid scaffold. Nanocarriers for drug delivery have been successfully created utilizing an electrospinning approach for a manuka honey treated polyvinyl pyrrolidine (Mh@PVP) hybrid composite. Different characterizations tools, including SEM, XRD, TEM, and FTIR. have been utilized to elucidate the fabricated electrospun nanofibrous scaffolds (ENS). The polyvinyl pyrrolidine (PVP) solutions' mechanical, tensile, and conductivity characteristics were greatly enhanced by adding increasing concentrations of Mh to the formula (15%, 20%, 25%). The width and direction of the ENS produced changed as the honey concentration increased. For wound healing, honey's ability to heal wounds faster may be boosted by a higher PVP concentration, which makes honey more easily incorporated. In an XRD investigation, honey and CT-TiONTs had a minor influence on the overall crystallinity of the ENS sample. Because of its burst-and-continuous methylglyoxal release patterns, which may last for up to seven days, manuka honey is an excellent choice for helping the body's healing process. The invivo assessment of the Mh@PVP nanocomposite nanofiber mat demonstrated a rapid and substantial increase in keratinocyte expression, reflecting great ability for high regenerative wound healing. Most significantly, there is no scarring associated with hair regrowth. This scaffold can mimic skin characteristics and stimulate keratinocyte development and act as a growth factor.

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